Released in five parts (The Persecution of the Children of Israel by the Egyptians, Forty Years in the Land of Midian, The Plagues of Egypt and the Deliverance of the Hebrews, The Victory of Israel, The Promised Land), 4 December 1909 to 19 February 1910. A Vitagraph advertisement in the Moving Picture World (31 Dec. 1909) refers to The Life of Moses as a "Biblical Film-de-Luxe". It is preserved in the Library of Congress collection.

Helene Palmer and her husband Orrin have grown apart, and she becomes infatuated with bachelor Edward Wadsworth. With the outbreak of World War I, Orrin and Edward enlist, while Helene works as a Red Cross nurse in a small French town. Edward is wounded on a dangerous scouting mission near the town and Orrin carries him to safety. The enemy invades during the night, and Orrin rescues Helene as she is about to be overpowered by a German officer. The dying Edward, morally strengthened by his experience as a soldier, encourages the couple to reunite. Soon after, peace is declared.

The true story of Edith Cavell, a British nurse who served with the underground in Belgium during the First World War.

Part two of Blackton's "The Life of Napoleon". After Waterloo, Napoleon reminisces. His triumphs are seen in flashback. The film ends with the exiled Napoleon overlooking the beach of St. Helena.