Poverty forces Helen Shirley, a country lass, into New York in search of a living. Shy and unsophisticated, Helen falls an easy victim of the notorious band which preys upon young girls and she is easily induced to go to a boarding house which is in reality the headquarters of the gang.

Young Frank Stratton, the scion of a wealthy family who is temporarily short of funds, has borrowed a valuable bracelet and hasn't returned it to its owner. A crooked detective, Jim Foley, finds the bracelet in Stratton's possession and promises not to arrest him for it in return for Stratton signing a confession that he stole it, which Foley intends to use at a future date. Years pass and a political boss in danger of losing an election asks Foley's help in getting valuable papers from his opponent, Worthington Lawrence. Foley knows that Lawrence is a friend of Stratton and tells Stratton that unless he steals those papers Foley will make his signed confession public. Complications ensue.

While visiting Monte Carlo with her aunt, Rosalie Dean meets a young man, Maxfield Gray who is ready to kill himself because of his losses at the roulette wheel. She stops him from doing so, and lends him some money to win back what he's lost. He does, but they're only happy for a short while before Max is arrested for the murder of his ex-wife in the States.

Produced at the Reliance studio in Yonkers, New York, HIS PICTURE IN THE PAPERS solidly established Fairbanks as the American ideal of pop, vim, and vigor. Furthermore, the film brought him together with the two collaborators who were to play a profound role in the evolution of his screen persona: writer Anita Loos and her future husband, director John Emerson. The theme was, according to Emerson and Loos, "the great American love of publicity."

Mark Embury sets out to create the perfect wife by adopting Peggy. His work is a success until the girl falls in love with another man. Ultimately, he must give her up and become satisfied with knowing, he did create the perfect wife, albeit for someone else.

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Lithuanian immigrant, Jurgis Rudkus, gains a job in the Chicago stockyards. Once working at the stockyards he meets and marries Ona. But due to cut backs at the stockyards, loses his job, and they fall into financial hardship. Ona, in order to get money to feed their child, engages in sexual activity with her husband's foreman, Connor. Connor, rapes her. When Rudkus finds out about the affair, he throws Connor into a cattle pen where he is killed. While in prison Ona dies. When Rudkus gets out of prison he becomes an advocate for women via the Socialist Party. Considered a lost film.

During World War I, John Stevens invents an anti-submarine device, but the plans are stolen by two German spies, the Baron von Wiederholtz and Madame Elsa, who flee to a New York hotel. Stevens' daughter Alice pursues the spies hoping to retrieve the plans.

Letty, a minister's daughter, rejects her devoted admirer George for the deceptive Captain Fanshawe. After Fanshawe ruins her reputation by tricking her into an overnight city trip, her father resigns in shame. Following a scarlet fever epidemic, the characters find redemption, and George ultimately marries Letty.

On the eve of her wedding to a man she does not love, young Felicite (Marguerite Clark) stumbles upon a diary written by one of her ancestors.

In India, Rosamond English learns that her husband, Capt. Harry English, has been killed in battle. After a time, she marries Sir Arthur Gerardine but is unable to forget her first husband, and gradually her love for him is rekindled, especially when she contrasts him to the pompous and elderly Sir Arthur.

The "girl" of the title was played by Hazel Dawn, a popular stage actress who briefly enjoyed a flourishing film career. Dawn plays Miss Shipley, an American girl vacationing in France. Our heroine finds herself the romantic bone of contention between two "men of the world" (William Roselle and Hal Clarendon), who end up fighting a duel over her affections.