Three years after the zombie virus has gutted the country, a team of everyday heroes must transport the only known survivor of the plague from New York to California, where the last functioning viral lab waits for his blood.

Fleeing her past, a troubled hiker and her dog traverse the Appalachian Trail, only to fall under the spell of a dangerous man. As obsession and visions mount, she's drawn toward Mile 666, where lust, death, and something ancient await.