The story follows General George Armstrong Custer's adventures from his West Point days to his death. He defies orders during the Civil War, trains the 7th Cavalry, appeases Chief Crazy Horse and later engages in bloody battle with the Sioux nation.

Arriving at Medicine Bow, eastern schoolteacher Molly Woods meets two cowboys, irresponsible Steve and the "Virginian," who gets off on the wrong foot with her. To add to his troubles, the Virginian finds that his old pal Steve is mixed up with black-hatted Trampas and his rustlers...then finds himself at the head of a posse after said rustlers; and Molly hates the violent side of frontier life.

On America's frontier, a St. Louis woman marries a New Mexico cattleman who is seen as a tyrant by the locals.

After some gun play with a posse, the James Gang head for Quinto in a section of land which is not a part of America. Anyone there is beyond the law so the town is populated with outlaws. Next to arrive is Sheriff Rowley, following his brother whom the Gang have brought in injured. Rowley has no authority and gets on well enough with the James boys but is soon involved in other local goings-on, including a move to vote for annexation with Oklahoma which would allow the law well and truly in.

Maisie becomes attached to a dirt-poor farmer and his family as they try to make ends meet joining hundreds of others digging for gold in a previously panned-out ghost town.

Billy the Kid and Fuzzy Jones are on their way out of Arizona being chased by some riders who hope to cash in on the reward money for their capture. They are warned in time by Ed Dawson, but Ed is wounded in the getaway. They get a doctor to attend to Ed. The latter tells them there is a range war in progress across the border and that he is looking for men to help make a cattle drive to the rail junction.

Saved from a lynching party by a pair of young women, an itinerant cowpuncher signs on as a stagecoach guard to protect a shipment of gold.

Notorious liar Windy Watkins is pursued by Marshal Flynn when he tells a story about mining in Northwest Canada and the murder of his partner.

Alec Lloyd, the foreman of the Sewell ranch, is nicknamed "Cupid" because of his propensity for matchmaking. When Macie Sewell returns from boarding school, Cupid himself falls victim to love, but Macie has aspirations to go to New York and become an opera singer, and so ignores his advances. However, Leroy Simpson, a poor doctor who is enamored of Macie's father's money, encourages her ambitions....

Hoppy, Lucky and California search for a mine owned by Trudy Pendleton after it was taken from her by thw swindling gambler Ace Gibson. They find the mine and Hoppy fights Gibson over it.