Asuka is an aspiring model who moves to Tokyo to pursue her career. She moves into a small apartment with a friend of a friend, Kasumi. A bizarre murder occurs in the hotel across the street. The body was mutilated and repositioned into a lurid work of art. After this, a string of murders start happening all around the two girls, as if some crazed serial killer was following them. At the scene of each crime, the perpetrator leaves a black lip print, and is subsequently dubbed "The Black Kiss."

Welcome to the Big House! It looks like any other prison, but this specialized penitentiary was designed from the ground up to hold Japan's most ruthless female inmates. That makes it doubly deadly, because while the guards may be brutal and sadistic, the inmates outnumber them by a hundred to one! At any second the final, fatal riot may erupt, stoking the flames of a thousand forbidden desires into an all-consuming inferno where it's every woman for herself! The shocking reality of Japan's secret prison system is exposed in Chain Gang Girls!

A powerful bond between two roommates is shattered when a malevolent entity transforms one of the women into a demonic murderess, in order to stop the bloody cycle of death, a terrified roommate must face her greatest fears.