This documentary examines ayahuasca shamanism near Iquitos (a metropolis in the Peruvian Amazon), and the tourism it has attracted. The filmmakers talk with two ayahuasqueros, Percy Garcia and Ron Wheelock, as well as ayuahuasca tourists and local people connected with the ayahuasca industry.

Micheal Smith is released from prison after serving four long years for a crime that he claims he did not commit. Within a few hours of his release, a man offers Michael a ride in his truck. From that moment on, the madness begins and the past slaps him in the face. The driver makes an attempt on Michael's life but he manages to escape, this time. The madman relentlessly pursues his, killing everyone in his path, and forcing Michael to play his deadly games.

In search of a miracle, an American woman embarks on a journey to the Peruvian Amazon and finds hope in a community, through rituals involving an ancient psychedelic plant known as ayahuasca. With her perception forever altered, she forges a bond with a young indigenous shaman undergoing a crisis of his own, and a motley crew of psychonauts seeking transcendence, companionship, and the meaning of life and death.