Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

Alicia Florrick boldly assumes full responsibility for her family and re-enters the workforce after her husband's very public sex and political corruption scandal lands him in jail.

Doctor Henry Morgan, New York City’s star medical examiner, has a secret. He doesn't just study the dead to solve criminal cases, he does it to solve the mystery that has eluded him for 200 years—the answer to his own inexplicable immortality. This long life has given Henry remarkable observation skills which impresses his new partner, Detective Jo Martinez. Each week, a new case and their budding friendship will reveal layers of Henry’s long and colorful past. Only his best friend and confidant, Abe knows Henry’s secret.

Billy & Billie centers on two young adults as they fall in love. They face the usual barrage of attention from their friends and family, and the normal anxieties that come at the start of a new relationship-all further complicated by the fact that they're stepbrother and sister.

A struggling musician enters into a chance affair with a married woman. The illicit encounters and resulting bond affect both in lasting and significant ways.

A man begins to suspect that his long-distance girlfriend, whom he met online but has never met in person, has been living in the same city the whole time and sets out to find her.