George Bailey has spent his entire life giving to the people of Bedford Falls. All that prevents rich skinflint Mr. Potter from taking over the entire town is George's modest building and loan company. But on Christmas Eve the business's $8,000 is lost and George's troubles begin.

Alice, the only relatively normal member of the eccentric Sycamore family, falls in love with Tony Kirby, but his wealthy banker father and snobbish mother strongly disapprove of the match. When the Kirbys are invited to dinner to become better acquainted with their future in-laws, things don't turn out the way Alice had hoped.

Two sailors on shore leave head out for four days of partying – only to become involved in the affairs of an aspiring singer and her precocious nephew.

Brothers Beau, John and Digby Geste join the Foreign Legion, where they fall under the rule of tyrannical Sergeant Markoff. Beau and John are assigned to Fort Zinderneuf, where Markoff tries to break their spirit, aware of a dark family secret concerning a fabulous jewel one of them carries. As tensions rise, Arabs attack the fort and rivalries must be thrown aside in a desperate battle for life.

A scientist working on cures for rare afflictions, such as a bone softening agent made from molds to allow him to correct the spinal deformity of his nurse, finds the physical causes of lycanthropy in wolf-man Larry Talbot and of vampirism in Count Dracula, but himself becomes afflicted with homicidal madness while exchanging blood with Dracula.

A woman's attempted murder of her uncaring husband results in everyday quarrels in the lives of Adam and Amanda, a pair of happily married lawyers who end up on opposite sides of the case in court.

Merchant Marine sailors Joe Rossi (Humphrey Bogart) and Steve Jarvis (Raymond Massey) are charged with getting a supply vessel to Russian allies as part of a sea convoy. When the group of ships comes under attack from a German U-boat, Rossi and Jarvis navigate through dangerous waters to evade Nazi naval forces. Though their mission across the Atlantic is extremely treacherous, they are motivated by the opportunity to strike back at the Germans, who sank one of their earlier ships.

Polly Parrish, a clerk at Merlin's Department Store, is mistakenly presumed to be the mother of a foundling. Outraged at Polly's unmotherly conduct, David Merlin becomes determined to keep the single woman and "her" baby together.

A hard-working, white-collar girl falls in love with a young socialite, but meets with his family's disapproval.

On America's frontier, a St. Louis woman marries a New Mexico cattleman who is seen as a tyrant by the locals.

Pat Pemberton is a brilliant athlete, except when her domineering fiancé is around. The ladies golf championship is in her reach until she gets flustered by his presence at the final holes. He wants them to get married and forget the whole thing, but she cannot give up on herself that easily. She enlists the help of Mike Conovan, a slightly shady sports promoter. Together they face mobsters, a jealous boxer, and a growing mutual attraction.

A Shakespearian actor starring as Othello opposite his wife finds the character's jealous rage taking over his mind off-stage.

In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.

Unjustly booted out of the cavalry, Mike McComb strikes out for Nevada, and deciding never to be used again, ruthlessly works his way up to becoming one of the most powerful silver magnates in the west. His empire begins to fall apart as the other mining combines rise against him and his stubbornness loses him the support of his wife and old friends.

Frenchwoman Michele de la Becque, an opponent of the Nazis in German-occupied Paris, hides a downed American flyer, Pat Talbot, and attempts to get him safely out of the country.

"Wicked" Lily Bishop joins a wagon train to California, led by Michael Fabian and Johnny Trumbo, but news of the Gold Rush scatters the train. When Johnny and Michael finally arrive, Lily is rich from her saloon and storekeeper (former slaver) Pharaoh Coffin is bleeding the miners dry. But worse troubles are ahead: California is inching toward statehood, and certain people want to make it their private empire.

Boring businessman Larry Wilson recovers from amnesia and discovers he's really a con man...and loves his soon-to-be-ex wife.

On the eve of World War II, the German Kurt Müller, his American-born wife Sara, and their three children, having lived in Europe for years, visit Sara's wealthy mother near Washington, DC. Kurt secretly works for the anti-Nazi resistance. A visiting Romanian count, becoming aware of this, seeks to blackmail him.

An American woman seeking divorce from her wealthy, controlling husband falls for a romantic Parisian who saves her from his entrapment.

An alcoholic woman was charged and tried for murder and a young defense attorney, unaware that she is his mother, takes the assignment to defend her in court.