Dr. Malcolm Sayer, a shy research physician, uses an experimental drug to "awaken" the catatonic victims of a rare disease. Leonard is the first patient to receive the controversial treatment. His awakening, filled with awe and enthusiasm, proves a rebirth for Sayer too, as the exuberant patient reveals life's simple but unutterably sweet pleasures to the introverted doctor.

A trio of interweaved transgressive tales, telling a bizarre stories of suburban patricide and a miraculous flight from justice, a mad sex experiment which unleashes a disfiguring plague, and the obsessive sexual relationship between two prison inmates.