In 1957, insurance investigator George Lazarus is tasked with interviewing twelve employees of the Deadly Sin Cigarette Company when his firm receives a suspicious insurance claim. He learns that all twelve had been let go after contracting mysterious illnesses, but before he can report back, Lazarus goes missing without a trace. After his disappearance, his fiancée Bethany and his friend Chip set out to find him - but what they uncover may actually signal the end of the entire human race.

A luxury cruise liner is requisitioned by the Greek government in an attempt to give safe passage to national treasures worth millions of pounds. The liner is attacked by an art collector who finds out about the plan. During the hijack the liner sinks to the sea floor and so begins a fight for survival as the remaining air begins to run out.