Tales from the Darkside is an anthology horror TV series created by George A. Romero, each episode was an individual short story that ended with a plot twist. The series' episodes spanned the genres of horror, science fiction, and fantasy, and some episodes featured elements of black comedy or more lighthearted themes.

Claire Gregory, an upper class New York personality, witnesses a murder in a luxurious nightclub. Detective Mike Keegan, recently promoted, is assigned to protect her.

Natalie allows her classmate Jeff, who has run away from home, to stay at her place while her father is away on a business trip. Natalie soon starts dating Jeff's friend James Casey, who isn't as faithful as she thinks, while her best friend Polly falls in love with baseball player Zoo Knudsen.

After witnessing her lover being murdered by his jealous wife, Angela seeks refuge in a church where she encounters a young priest named Michael, who gives her sanctuary. But the killing was not a simple act of passion, as the victim had ties to organized crime, and, surprisingly, so does Michael, whose father is a powerful don. When the priest finds himself falling in love with Angela, his religious vows and family ties are both severely tested.

Spike Fumo is an Italian kid apsiring to be a boxer. He falls in love with a rich girl, who turns out to be the daughter of a Mafia boss. Spike is threatened to leave Bensonhurst by the mob, and then goes to a poverty-stricken Puerto Rican part of Brooklyn.

New York urologist Harold Lear gets a taste of his own medicine when he suffers a heart attack and is confronted with a medical institution which doesn't seem equipped to help. Wife Martha steps in to fight the system and get a measure of service and compassion. Ultimately the greatest battle is not waged against the medical profession, however, but against Lear's own failing body and his own mortal fears.

Eddie Brennan is a down-and out fighter with nowhere to go but up... and with just the right combination of guts and spirit to become a winner. Once a contender, Brennan is now a washed-up has-been living in a fantasy world halfway between the dreams of his glory days and the dreams of a comeback. And when a set-up fight disguised as a legitimate bout comes his way, he jumps at the chance. No one thinks Eddie can win... least of all his trainer. No one wants Eddie to win... especially the crooked promoters. But Eddie's got something to prove to them all... and to himself. And he'll do anything to show that he's got the heart it takes to be a winner.

A humanoid alien lands on earth, and soon discovers he likes to eat Italian. Italian people, that is. Incompetent detective McSorely is the only one with a clue about what's going on, and even his grasp of the situation isn't too firm. The rest of the police force thinks he's crazy, while the alien continues sampling the Italian cuisine of New York City.

An ex-con and break-dancer helps save a neighborhood from a greedy developer while trying to win a rap contest.