20-something Angus MacGyver creates a clandestine organization where he uses his knack for solving problems in unconventional ways to help prevent disasters from happening.

Notorious serial killer Joe Carroll, after being found guilty of murdering 14 female students on the Virginia college campus where he taught literature, escapes from death row. The FBI calls former agent Ryan Hardy to consult on the case, as he was the one responsible for Carroll’s capture in 2003. Ryan, working closely with an FBI team, including Mike Weston and FBI Specialist Debra Parker, piece together the ever-growing web of murders orchestrated by the devious Carroll.

In any given year, more than 600,000 people are reported missing in the U.S. Of these reported cases, more than half of the missing people are people of color, too easily neglected by the system. Gabi Mosely, a former missing person herself, now specializes in PR and leads a crisis management team that seeks out these missing people. But unbeknownst to anyone, Mosely is hiding a dark secret of her own.

Mom Nancy, a schoolteacher, is unable to handle the constant barrage of hostility from her three children. Husband Ira is ineffectual in helping his wife with her anxiety. Older son Mikey is barely able to express himself. Middle child Meghan flouts whatever restrictions her parents place on her, and youngest child Spencer, needs to be handcuffed to the car just to participate in family outings.