Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

A vast international plot explodes when a beautiful Jane Doe is discovered naked in Times Square, completely covered in mysterious, intricate tattoos with no memory of who she is or how she got there. But there's one tattoo that is impossible to miss: the name of FBI agent Kurt Weller, emblazoned across her back. "Jane," Agent Weller and the rest of the FBI quickly realize that each mark on her body is a crime to solve, leading them closer to the truth about her identity and the mysteries to be revealed.

Notorious serial killer Joe Carroll, after being found guilty of murdering 14 female students on the Virginia college campus where he taught literature, escapes from death row. The FBI calls former agent Ryan Hardy to consult on the case, as he was the one responsible for Carroll’s capture in 2003. Ryan, working closely with an FBI team, including Mike Weston and FBI Specialist Debra Parker, piece together the ever-growing web of murders orchestrated by the devious Carroll.

Look who’s making the news again! One of NY’s most beloved news anchors, Mike Henry (Michael J. Fox), put his career on hold to spend more time with his family and focus on his health after he was diagnosed with Parkinson’s. But now five years later, with the kids busy growing up and Mike growing restless, it just might be time for him to get back to work. Having never wanted Mike to leave in the first place, his old boss Harris Green jumped at the chance to get him back on TV. The trick, as it’s always been, was to make Mike think it was his idea. After several – okay, many - failed attempts, Mike’s family, anxious to see him out of the house, finally succeeded in getting him to “run into” Green. Now their plan is in motion. He’ll be back to juggling home, family, and career, just like the old days – only better.

A detective tries to track down a masked killer who reappears every Halloween to wreak bloody havoc.

Rosalina comes back after her music cruise, but Michel (the French guy Rosalina kissed on the cruise) also comes back, criticizes Nat's music, and kisses Rosalina which Nat sees. This causes a heated fight between Nat and Rosalina in which they break up and Rosalina quits the band.

When a Dominican teenager attends a fundraising gala for her youth mentorship program it forces her to face some uncomfortable truths about her place in the world.