Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

Harmon "Harm" Rabb Jr. is a former pilot turned lawyer working for the military's JAG (Judge Advocate General) division, the elite legal wing of officers that prosecutes and defends those accused of military-related crimes. He works closely with Lt. Col. Sarah Mackenzie, and together they do what needs to be done to find the truth.

Common people discover that they have super powers. Their lives intertwine as a devastating event must be prevented.

Perhaps their strikingly different personalities make the relationship between detective Jane Rizzoli and medical examiner Maura Isles so effective. Jane, the only female cop in Boston's homicide division, is tough, relentless and rarely lets her guard down, while the impeccably dressed Maura displays a sometimes icy temperament — she is, after all, more comfortable among the dead than the living. Together, the best friends have forged a quirky and supportive relationship; they drop the protective shield in each other's company, and combine their expertise to solve Boston's most complex cases.

Dr. Michaela Quinn journeys to Colorado Springs to be the town's physician after her father's death in 1868.

The Duncans a European-American family in Colorado is adjusting to the surprise birth of their fourth child, Charlie. When parents Amy and Bob return to work they put their latest addition in the care of her three older siblings, PJ, Teddy, and Gabe. Teens PJ and Teddy and tween brother Gabe are typical kids -- that is, until their mother has another baby. The arrival of their new sister completely upends the entire household. When their mother heads back to work after Charlie's birth, it's up to the kids and their dad to keep the home fires burning -- and to keep Charlie out of trouble as she learns to sit up, crawl, walk and run. Teddy, as the older sister, makes a personalized video diary for Charlie, in each episode adding a nugget of wisdom for her baby sibling.

In the early 21st century, mankind has colonized the oceans. The United Earth Oceans Organization enlists Captain Nathan Bridger and the submarine seaQuest DSV to keep the peace and explore the last frontier on Earth.

Single working mom Christine Campbell has just learned that her ex is dating a much younger woman with the same first name. To avoid any confusion, the new girlfriend is dubbed New Christine, which leaves her with the unfortunate nickname Old Christine.

Dr. Nathaniel Grant is a pioneering organ-transplant surgeon who takes risks that other doctors would not in order to save the lives of his patients. He works closely with his ex-wife, Kate Armstrong, an organ-donor coordinator with whom he has a volatile relationship. Grant's arrogance and willingness to perform risky procedures causes him to butt heads with the hospital administration. But his main focus is on his intense relationship with his job and his patients, often at the expense of his family.

Based on the autobiographical novel, the tempestuous 6-year relationship between Liberace and his (much younger) lover, Scott Thorson, is recounted.

Psychiatrist Ed Altman relocates to Palm Springs in order to avoid a lawsuit. However, he wanders directly into more trouble when he begins an affair with the wealthy Ally Mercer, who has her own motives for getting involved with Ed. Soon Ally's volatile lover Nick is caught in the intrigue, resulting in shady dealings, betrayal, and, ultimately, murder.