Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

Steve McGarrett returns home to Oahu, in order to find his father's killer. The governor offers him the chance to run his own task force (Five-0). Steve's team is joined by Chin Ho Kelly, Danny "Danno" Williams, and Kono Kalakaua.

After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.

A sidekick who tries to do good by the city he swore to protect despite the villains and new superhero that stand in his way.

Over the course of a single day the lives of innocent and not-so-innocent individuals collide in a web of misfortune and redemption.