Takeshi Hongo is a promising young man with a passion for motorcycle racing. However, his dreams are suddenly ruined when he gets kidnapped by Shocker, the evil secret organization planning to dominate the world. After being remodeled into a cyborg, Takeshi escapes and swears to protect the world from the inhuman monsters.

Four young physicians are assigned to the “Doctor Helicopter” system, the latest medical system where a medical team is dispatched to the patients via helicopter to provide medical care in the field as soon as possible. The doctors experience traumatic medical situations, deal with personal ambitions, and witness the fragility of life, all while growing personally and professionally.

In an alternative feudal Japan, a strange disease that only affects males caused a massive population reduction, leaving females to fill the vacant jobs, therefore changing the social structure. Now, 80 years after the initial outbreak with a 1:4 male:female ratio, Japan is a completely matriarchal society. Females hold all important political positions, and males are their consorts. Only the most powerful female—head of Tokugawa shogunate—may keep a harem of handsome and unproductive males, known as "Ōoku".

Hatanaka Kosaku is a talented boxer who turned pro at the age of 19, winning his debut match with a first round KO. He is talented, but he has no guts. His uncontrollable appetite is an even bigger problem. He can't put himself in the right weight class, he runs out of energy because of hunger, and he gets knocked out while his eyes are set on food at the ringside. However, Kosaku's life changed when he met Sister Angela, a novice nun in the convent near his boxing gym. She became the source of his power, and Kosaku fights only to win her heart.

Taro Yamada is a scholarship student at Ichinomiya High School. He’s smart, athletic, and handsome—so everyone assumes he’s wealthy. In reality, he lives in poverty with his mother and six younger siblings in one small room, and his father Kazuo is an absent wandering artist. Taro works part-time to support the family. Together with his best friend Takuya Mimura and classmates, Taro navigates comedic and touching moments. Through friendship, romance, and family bonds, the series asks what true happiness really means. It’s a heartwarming coming-of-age story.

High school student Hoshi Izumi loses her father suddenly in an accident. One day, Sakuma, the waka gashira of a small and weak Yakuza gang in Asakusa - the Medaka Gumi - pays Izumi a visit along with the gang members. The death of their former kumicho (Boss) puts Medaka Gumi on the verge of a breakup. Therefore, Sakuma begs Izumi, the former boss's only distant relative left, to succeed to the kumicho position. Izumi is taken by surprise and keeps refusing at first. However, she ends up becoming the 8th kumicho of the Medaka Gumi! The police tell her that her father's death may possibly be a homicide case. There's also Mayumi, a mysterious woman staring closely at Izumi's father's photograph at his funeral. The situation becomes complicated when the drug-dealing vicious yakuza, Hamaguchi Gumi, comes into the picture as well as Sandaiji Hajime, a politician whose public stance is to eliminate drugs.

Ryotsu Kankichi, nicknamed Ryo-san, is a senior patrol officer working at the Kamearikoen-mae police box at Katsushika. Because of his daring, hearty, unconventional, haughty and overbearing personality, he is called "letter of apology Ryo-san" and everything he does is nonsense. There is endless trouble wherever Ryo-san goes. He makes Akimoto Catherine Reiko and Nakagawa Keiichi, his juniors from the same police box, fearful. His superior, Ohara-buchou, lives each day as if lightning will strike as a fearless power keeps going off day after day. He definitely doesn't have poor ability as a "patrolman of the police box" in the mediation of quarrels, taking care of New Year's gifts or discussion of neighbourhood problems but he has a bad temper, gets tired of things easily and detests working. He is a police officer but because he loves gambling, he spends his money recklessly and in addition to this mess, is heavily in debt. He has a weakness for get rich quick schemes, and has a manic desire and knowledge to have fun and make money. Then one day, Ryo-san receives a tempting proposition...

A male corpse is discovered with a smashed face and burned hands. Strangely, the cause of death is determined to be strangulation. When Detective Kaoru Utsumi attempts to corroborate the victim’s ex-wife’s alibi she discovers the mysterious neighbor and only a few small clues to help her disprove a seemingly "airtight" alibi...

Takahiko Tokito is a doctor at a big medical corporation. He has decided to run away with his lover, the wife of the president of his company. But before he is able to leave, he has to kill her husband and make it look like suicide.

Detective Shirō Yuge (played by Yū Shinagawa) from the Kitazuka North Police Station revisits the bizarre “Den’enchōfu Rat-Man” case—a horrific crime involving victims eaten by rats. Initially presumed solved in Galileo, unsettling evidence of a copycat and possible accomplice emerges, pulling Yuge back into a chilling investigation.