Best Friends follows the life of a group of friends at their high school ‘Spangalis College’. Inside and outside of school exciting and challenging experiences take place. Growing up is never easy; every character has its own, unique story of love, friendship, loneliness, sorrow, discovery. There is drama and joy in school, family, teachers, parents, divorce, bullying, and always dreams for the future.

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News that the school is supposed to suddenly close causes great agitation among the students. They decide to take direct action by occupying their school... The siege commands hard-action from the friends to protect their school and identities. Will they convince the board to keep the school open?

When a boy is framed after an act of senseless violence by his friends, they turn against him for trying to tell the truth.