The story of New Jersey-based Italian-American mobster Tony Soprano and the difficulties he faces as he tries to balance the conflicting requirements of his home life and the criminal organization he heads. Those difficulties are often highlighted through his ongoing professional relationship with psychiatrist Jennifer Melfi. The show features Tony's family members and Mafia associates in prominent roles and story arcs, most notably his wife Carmela and his cousin and protégé Christopher Moltisanti.

Marcus Burnett is a henpecked family man. Mike Lowrey is a footloose and fancy free ladies' man. Both Miami policemen, they have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug Ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

After Roberta Guaspari separates from her husband, she receives encouragement from her mother to take up a job of a music teacher at the Central Park East School in East Harlem.

The story is about a married couple with children on the verge of divorce. Their imminent divorce, like many, is due to their mutual lack of respect and compassion for each other and the effect it has on their children. When the family makes a traumatic move to New Orleans they move into an old, Victorian home. There, in the attic, the children think they have found the "magic" to solve their parent's problems. The children accidentally manage to switch the souls of their parents. Now the wife must face the perils of the lockeroom and pressures as family breadwinner and the husband must face pregnancy and bond with his children. Newfound respect and appreciation is gained as the couple finally find out what it's like to walk in the other person's shoes.