Like Jim Carrey's Eternal Sunshine of the Spotless Mind, Engrams is a wild, fun trip that delves into the human mind and our complex emotions by examining a young scientist who attempts to cure depression by triggering happy memories. When his girlfriend destroys everything that defines her personality, it starts a chain of events that sends him on a global search for his lost love.

Four wealthy country club wives come to an empty mansion to bid on the diary of a deceased pool boy who they all had affairs with. Once there, a Goth spirit medium hired to scare them actually opens the door to the other realm and the ghost of the deceased refuses to let anyone leave until he finishes playing all his cards.