After Doug picks up hitchhiking Rosco with his truck, they are mistaken for two bank robbers by the traffic police. They manage to escape only to be confused for two secret agents while trying to take a flight at the airport.

The Enos duo convince Cletus, aka The Bandit, to come out of hiding and help them promote their new restaurant. With a little coaxing, he agrees, producing an almost-creaky Trigger as his mode of transport. But his nemesis, Sheriff Buford T. Justice, is on the hunt, forcing Cletus and Trigger to hit the road. Can they steer clear of the vengeful sheriff?

While everyone knows you can't fight City Hall, there are those who, for whatever reason, can't resist the challenge. Three slightly disturbed psychiatric patients decide to take on the government. What ensues includes car chases, a ferry boat hijacking, strip-teases and lots of fun!