Takeshi Hongo is a promising young man with a passion for motorcycle racing. However, his dreams are suddenly ruined when he gets kidnapped by Shocker, the evil secret organization planning to dominate the world. After being remodeled into a cyborg, Takeshi escapes and swears to protect the world from the inhuman monsters.

Seishiro Tokai (Kazunari Ninomiya) works as a surgeon at a university hospital. He possesses excellent technique with suture and carries a surgery success rate of 100%. Due to his arrogant attitude and personality, he comes into conflict with those around him. A new doctor tries to introduce the latest medical device for surgery, which doesn't need a surgeon's hand. Seishiro Tokai is skeptical of the device. He faces the university hospital administration and reveals corruption and hidden past behind the medical device.

Leading an expedition in Germany, Kougami unseals the resting place of one of the alchemists that created the Core Medals in an effort to retrieve a set of lost Medals. However, upon the seal being undone, millions of Cell Medals erupt into a tower while creating a magical barrier that causes parts of Japan to flip over. As the alchemist reveals her plans to become a new OOO, Eiji and his friends are thrown into the past and must find their way back home and stop the alchemist before she destroys the world!

For Fujiwara, everything seems to be going well - he is doing well in high school, he is good looking and also a good fighter. One day, he is suddenly attacked by a group of students without any provocation. He then discovers that there is a mysterious violent game being played out in the corridors and playfrounds of Tokyo’s high schools. The game is being spread virally via the students’ mobile phones! The victims are mysteriously hypnotized and become senseless killing machines. Fujiwara must fight for his survival and to discover the game’s terrifying secret.