Dr. Michaela Quinn journeys to Colorado Springs to be the town's physician after her father's death in 1868.

An interracial love story, set in the turbulent wild west, stirs up tensions between the Indians and the settlers.

Two Northern Cheyenne men take a road trip from Montana to New Mexico to bail out the sister of one of them who has been framed and arrested in Santa Fe. On the way, they begin to reconnect to their spiritual heritage.

A female mayor of Albuquerque gets embroiled in a fight over the development of a new economic center. In the midst of this, she receives blackmail photos of an overnight fling she had with a stranger and threats of blackmail. On top of all this, the city is under siege by a serial killer who hunts powerful women. When the FBI moves in for the investigation, the chief officer turns out to be the stranger.

The 1854 Wyoming historical drama is based on Tom Shell's adaptation of the true life memoirs of Pony Express rider Nick Wilson.

The Deputy Marshall tracks down an escaped convict along with a young deputy and the help of a former prostitute.