The story of New Jersey-based Italian-American mobster Tony Soprano and the difficulties he faces as he tries to balance the conflicting requirements of his home life and the criminal organization he heads. Those difficulties are often highlighted through his ongoing professional relationship with psychiatrist Jennifer Melfi. The show features Tony's family members and Mafia associates in prominent roles and story arcs, most notably his wife Carmela and his cousin and protégé Christopher Moltisanti.

In the midst of trying to legitimize his business dealings in 1979 New York and Italy, aging mafia don, Michael Corleone seeks forgiveness for his sins while taking a young protege under his wing.

The mafia's Paul Vitti is back in prison and will need some serious counseling when he gets out. Naturally, he returns to his analyst Dr. Ben Sobel for help and finds that Sobel needs some serious help himself as he has inherited the family practice, as well as an excess stock of stress.

A story which centers around Dave Katz, a journalist at a hip-hop magazine who is sent on assignment to uncover the often comedic underworld of Roc-a-Fella Records run by Damon Dash and Jay-Z.

A working girl from New Jersey looks for love with a fast-lane Manhattan salesman from Queens.

Faith is a young dancer, whose parents are killed in a plane crash. Dancing is her refuge, but the streets of Los Angeles can be dangerous for a lonesome woman.