When they were boys, Sam and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it. Now, the Winchester brothers crisscross the country in their '67 Chevy Impala, battling every kind of supernatural threat they encounter along the way.

Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.

Bored and unhappy as the Lord of Hell, Lucifer Morningstar abandoned his throne and retired to Los Angeles, where he has teamed up with LAPD detective Chloe Decker to take down criminals. But the longer he's away from the underworld, the greater the threat that the worst of humanity could escape.

Homicide detective Tess Avery is forced to quit the job she loves after nearly killing her partner and being diagnosed as clinically blind. Reluctant to accept help, Tess uses an assistance app and connects with Sunny Patel, a professional seeing-eye guide and agoraphobe living 3,000 miles away. Haunted by the unsolved cases she left behind, Tess uses a hidden camera and earpiece, while Sunny remotely steers Tess through life's obstacles -- and crimes -- as the two challenge preconceptions about ability, trust and where to draw the line.

Distraught patients recently diagnosed with STIs look back on how they contracted the disease and what they could have done to prevent the transmission.

A recently single Jessica sends Christmas cards to people who have impacted her life—the aunt who raised her, her younger brother in the military, a popstar who was part of the soundtrack of her life, the music teacher who inspired her, and the best friend who always tells the truth.

The POstables are on a mission to deliver a soldier's letter from Afghanistan to a teenager who's being relentlessly bullied, while Oliver's estranged father surprises him with news that shakes him to his core.

After undergoing surgery that was supposed to cure her pain and disability, Sydney now experiences memory loss associated with specific memories of her traumatic incident and certain physical gestures.

Margot, a world-renowned pianist, returns to Chateau Newhaus to spend the holidays with her family and is reunited with an ex who helps her rediscover her passion for music.

Shy artist Isla is shocked when her painting is accidentally sold to charismatic salesman Mark, whose boss wants to commission Isla for a sculpture. Mark, hoping to impress his boss, talks Isla up and gets her to do the job, but there’s one problem…Isla’s never sculpted before. With Mark’s encouragement, Isla’s confidence blossoms and so does their love.