Professor Joe Howe is a Korean War veteran who is hired to teach English at Channing College. The dean Fred Baker is his mentor as Howe is writing a novel about his experiences. They are frequently involved in the student's lives. Channing, a production of Revue Studios, aired during the same time frame as the first season of NBC's somewhat similar offering, Mr. Novak.

With the help of student assistant Boris and stolen university equipment, Dr. Harry Wolper plans to clone his dead wife. But then he meets Meli, an egg donor for his experiment, and they fall in love. Faced with choosing between his deceased wife and Meli, Dr. Wolper sees his situation in a new light when Boris' own new love, Barbara, falls into a coma. Meanwhile, another professor tries shutting down the cloning project.

Four suburban housewives, with a love for the theater, set out to foil an unscrupulous talent agent who has threatened to blackmail another woman to the point of an attempted suicide.

Jack Farley and his family are asked to attend an experiment about social behavior for a planned space station. Therefore they move into an underground dome for three months. But then it turns out that a secret military department replaced the NASA scientists and conducts an experiment on its own...