Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

Twenty-four-year-old Kara Zor-El, who was taken in by the Danvers family when she was 13 after being sent away from Krypton, must learn to embrace her powers after previously hiding them. The Danvers teach her to be careful with her powers, until she has to reveal them during an unexpected disaster, setting her on her journey of heroism.

The rivalries, romances, hopes and fears of the residents of the fictional Midwestern metropolis, Genoa City. The lives and loves of a wide variety of characters mingle through the generations, dominated by the Newman, Abbott, Baldwin and Winters families.

A group of five American friends on the cusp of adulthood travel to Panama to relax and reconnect. They befriend a local woman in their hotel bar—and despite some ominous whispers—she goes against the specific instructions of her brother and brings the Americans on a daytrip into the pristine falls at the nearby jungle. What begins as an innocent outing to a picturesque waterfall quickly turns terrifying after she suddenly goes missing. As night closes in, the friends realize too late the truth behind the rumors—the legendary, blood-sucking Chupacabra is now stalking them.