Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.

A secret society, somewhere in France, is responsible for the major unsolved murder mysteries throughout history (such as Henri IV, Lincoln, Kennedy, John-Paul I)...