The exploits of the Los Angeles–based Office of Special Projects (OSP), an elite division of the Naval Criminal Investigative Service that specializes in undercover assignments.

Inspired by actual cases and experiences, Numb3rs depicts the confluence of police work and mathematics in solving crime as an FBI agent recruits his mathematical genius brother to help solve a wide range of challenging crimes in Los Angeles from a very different perspective.

Three fabulous, eccentric, LA best friends of a certain age have their lives changed forever when their plane unexpectedly lands in Cleveland and they soon rediscover themselves in this new "promised land."

Once upon the 1970s, Dan Stark and his partner, Frank Savage, were big-shot Dallas detectives. So big, in fact, that they were lauded as American heroes after saving the Governor's son. Thirty years later, Dan Stark is a washed-up detective who spends most of his time drunk or re-hashing his glory days. Dan's new partner, Jack Bailey, is an ambitious, by-the-book and overall good detective, but is sometimes a bit too snarky for his own good. His habit of undermining himself has earned him a dead-end position in the department, and he is stuck solving annoying petty theft cases that nobody else wants. Worse, he's been given the thankless task of babysitting Dan, the drunk pariah who can never keep partners for long.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.

Mr. Jack and Sweet Stephen cruise aimlessly through the streets of LA speculating about life, death, divine will and the force of power that predetermines their existence. Mr. Jack attempts to illustrate to his sidekick the delicate and natural forces of the universe. Sweet Stephen's superficial charm and bloodsucking lifestyle sends him and Mr. Jack on a voyage that is relentless, engaging, and darkly hilarious.

After her husband leaves her for a younger woman, Alice Washington a middle aged mother of two decides to complete her college education at Smith College. She and her 20 year old room mate Zoe Burns share their experiences, conflicts and interest in their poetry professor.

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