A group of Malayali nurses stranded in Iraq, must survive their capture by the extremists and reach out to the rescue team headed by the Indian government.

Mandharam begins with the all too familiar trope - the schoolboy who spends his days dreaming about his childhood sweetheart and classmate, who, at the end of school, lets him know that she has a 'muracherukkan'.

Daivathinte Swantham Cleetus revolves around Cleetus (Mammootty), a dreaded long-haired rogue. He surprises the parish priest (Siddique) by his uncanny resemblance to Jesus Christ in looks and mannerisms. He is roped in by the priest for the role of Jesus Christ for a light and sound show for their upcoming festival. His real self comes to the fore during rehearsals. The fact that he is a goon is revealed, yet the priest decides to persist with him in the belief that the experience of performing the noble character will lead to his transformation. Things change in the life of Cleetus after that. Events that occurred in the life of Jesus Christ start occurring in the life of Cleetus too. What happens to Cleetus and the people surrounding him form the rest of the story.

After living 23 years in France, psychiatrist Dr. Roy is called back to his village by Fr Francis, the man who raised him during his childhood. He has no idea why he was asked back, but when he returns he meets his childhood friend Dr Meera Menon who has become a pediatrician, but meeting her again brings him memories of their being in love years earlier.