When they were boys, Sam and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it. Now, the Winchester brothers crisscross the country in their '67 Chevy Impala, battling every kind of supernatural threat they encounter along the way.

Twenty-four-year-old Kara Zor-El, who was taken in by the Danvers family when she was 13 after being sent away from Krypton, must learn to embrace her powers after previously hiding them. The Danvers teach her to be careful with her powers, until she has to reveal them during an unexpected disaster, setting her on her journey of heroism.

Ever since she was a little girl, Iris has wanted to be a filmmaker. For the last five years though, she's been trapped working in reality television, directing episodes for a series that's barely able to compete with Ghost Hunters. Iris sees her big chance to prove herself when she gets sent on assignment to her hometown of Black Falls, a small town harboring an abandoned insane asylum that has a dark history of excessive shock therapy. Filming inside the asylum brings back childhood memories for Iris, memories of sneaking into the asylum with her friends to shoot homemade horror movies. Little does Iris know, her life is about to imitate her art.