A tough, brilliant senior resident guides an idealistic young doctor through his first day, pulling back the curtain on what really happens, both good and bad, in modern-day medicine.

Hollywood, 1927: As silent movie star George Valentin wonders if the arrival of talking pictures will cause him to fade into oblivion, he sparks with Peppy Miller, a young dancer set for a big break.

Catherine Black is a world-famous neurologist at the state-of-the-art medical institution known as "The Cube". Catherine is brilliant, beautiful, and at the top of her game, though she's hiding a secret of her own: she's bipolar. Each week, the doctors on staff attempt to unravel the mysteries of the brain and are constantly challenged by cases never-before-seen on television. The medical stories are moving, bizarre and a visual feast. The personal stories are riveting. The patients have rare, highly visual, often hallucinogenic and startling conditions, which we’ll see through their eyes as Catherine diagnoses and treats them.

Evelyn, a recently retired widow, masks her paralyzing worry about the future with the comfort of routine. But when her son, Asher, moves back home after graduating from college, his parallel anxieties amplify Evelyn's internal crisis.