The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

Mary Ann returns to present-day San Francisco and is reunited with her daughter and ex-husband, twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal, her chosen family and a new generation of queer young residents living at 28 Barbary Lane.

When Anna offers a stranded mother and son shelter in a blizzard, she learns that they are the Royal Family of Galwick. Anna shows the Prince how they do Christmas in her hometown, encouraging him to open his heart and be true to himself.

Taylor is forced to hide the young daughter of a Colombian woman in witness protection who will be testifying against a powerful drug cartel in Federal Court, as ruthless sicarios aim to hunt them down.

Blanche Montgomery finds herself in the a dangerous mix of paranoia and frustration as stories emerge of a Serial Killer who has been terrorizing the neighborhood she is currently living in.