The human world is attacked by the space outlaw group the Dethgaliens who have chosen the Earth to be the site of their 100th Blood Game. One human and 4 anthropomorphic Zyumans awaken their instincts to become the Zyuohgers and fight to protect all living things.

Mihiro is a young girl who lost her mother at a young age, while Haruto is a father pursuing the vision of his dead wife. Both are at the mercy of conflicting love and are thrust into tragedy.