Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

A platonic pair of former best friends approaching midlife reconnect after a long rift. The duo’s friendship becomes more consuming—and destabilizes their lives in a hilarious way.

Nell Serrano is a broke and newly single self-described disaster. She works to restart the life and career she left behind some 10 years ago. When writing obituaries is the only job she can find, Nell starts getting life advice from an unlikely (and dead) source.

Ryan King, a recent widower and sports talk radio host ready to get back to work after the loss of his wife. Ryan's alpha-male boss, Stephen, has a different plan in store for Ryan, making him attend grief counseling before returning to the air. A reluctant Ryan finds himself in a support group for "life change," where he meets an oddball cast of characters, all with their own backstories filled with varying degrees of loss.

While traveling across the country in a run-down RV, drag queen Ruby Red discovers an unlikely sidekick in AJ: a tough-talking 10-year-old stowaway.

Los Angeles couple Bryan and David have successful careers and a loving relationship and are ready for a baby. Just as they start to worry that they will never be blessed with parenthood, they meet Goldie, a waitress who has just moved to California with her precocious eight-year-old daughter to escape from her closed-minded grandmother and a life without a future. The guys quickly work out a deal with Goldie to become their surrogate, and in the process, the little group forms a unique family unit of its own.