Four Star Playhouse is an American television anthology series that ran from 1952 to 1956, sponsored in its first bi-weekly season by The Singer Company; Bristol-Myers became an alternate sponsor when it became a weekly series in the fall of 1953. The original premise was that Charles Boyer, Ida Lupino, David Niven, and Dick Powell would take turns starring in episodes. However, several other performers took the lead from time to time, including Ronald Colman and Joan Fontaine. Blake Edwards was among the writers and directors who contributed to the series. Edwards created the recurring character of illegal gambling house operator Willie Dante for Dick Powell to play on this series. The character was later revamped and spun off in his own series starring Howard Duff, then-husband of Lupino. The pilot for Meet McGraw, starring Frank Lovejoy, aired here, as did another episode in which Lovejoy recreated his role of Chicago newspaper reporter Randy Stone, from the radio drama Nightbeat.

When Dr. Anthony Edwardes arrives at a Vermont mental hospital to replace the outgoing hospital director, Dr. Constance Peterson, a psychoanalyst, discovers Edwardes is actually an impostor. The man confesses that the real Dr. Edwardes is dead and fears he may have killed him, but cannot recall anything. Dr. Peterson, however is convinced his impostor is innocent of the man's murder, and joins him on a quest to unravel his amnesia through psychoanalysis.

A man of humble beginnings and honest intentions rises to power by nefarious means. Along for the wild ride are an earnest reporter, a heretofore classy society girl, and a too-clever-for-her-own-good political flack.

Following a tragic accident that leaves him disfigured, crazed composer Erique Claudin transformed into a masked phantom who schemes to make beautiful young soprano Christine Dubois the star of the opera and wreak revenge on those who stole his music.

An attorney defends a hoodlum of murder, using the oppressiveness of the slums to appeal to the court.

After years of investigation, Assistant District Attorney Martin Ferguson has managed to build a solid case against an elusive gangster whose top lieutenant is about to testify.

In 1903, Doctor Huntington Bailey meets a friendly older lady during a train trip. She tells him that she is going to visit her brother Nick and his lovely young wife Allida. Once in New York, Bailey hears that his train companion suddenly died. Shortly afterward, he meets the strange couple and gets suspicious of Nick's treatment of his wife.

As novice detectives, Bud and Lou come face to face with the Invisible Man.

After being found wandering the streets of Los Angeles, a severely catatonic woman tells a doctor the complex story of how she wound up there.

A young man succumbs to gambling fever.

An Australian nurse discovers an effective new treatment for infantile paralysis, but experiences great difficulty in convincing doctors of the validity of her claims.

Frank Warren is a treasury agent assigned to put an end to the activities of a powerful mob crime boss. Frank works undercover, posing as a criminal to seek information, but is frustrated when all he finds are terrified witnesses and corrupt police officers.

Ignored by his alcoholic parents, Jimmy Wilson starts hanging around with some shady characters. After falling in love with a lounge singer, Jimmy tries to impress her by doing jobs for her shady boss. After one of these jobs goes bad, Jimmy ends up on the run. Eventually, he must confront the truth, his past, and his parents. The judge cites parental neglect in the case of a teenager (John Miljan) charged with murder.

In this biopic, Jim Bowie goes to New Orleans, where he falls for Judalon and befriends her brother, Narcisse. Soon, Jim is forced to avenge Narcisse's murder, but Judalon takes up with another man. Jim eventually has another romantic interlude with Judalon and is forced to kill one of her suitors in self-defense. Jim leaves town, and falls for the daughter of a Texas politician, but his entanglement with Judalon continues to bedevil him.

A crime gang leader is losing her sight, so while her lover goes into hiding, she checks in to the hospital for extensive surgery to recover her eyesight. There she is treated by a handsome young doctor. As expected not only does the doctor successfully open her eyes, he also opens her heart for him.

Shipwreck survivors land on an uncharted island inhabited by prehistoric beasts.

Ice-cold college dean Susan Middlecott feels there's no room in her life for romance. Enter Prof. Alec Stevenson, British lecturer on astronomy, touring North America and in possession of a keepsake of Susan's he wants to return. Desperate for publicity, lecture bureau press agent Teddy Evans magnifies this into a great romance. The efforts of both dignified principals to quash the story have the opposite effect; matters get more and more involved.

An actor becomes a suspect in the murders of four New Yorkers injected with rattlesnake venom.

A police lieutenant and a patriotic professional gambler, rivals in life and love, combine efforts to corner a gang of Nazi saboteurs operating out of a barber shop, in which their mutual girlfriend works, and unmask its secret leader.

Ex-police/army dog King inherits a fortune from an eccentric millionaire. But someone poisons him for his fortune. He gets to go back to earth as a human detective to bring his killer to justice and protect the girl who used to look after him.