New York, 1896. Police commissioner Theodore Roosevelt brings together criminal psychologist Dr. Laszlo Kreizler, newspaper illustrator John Moore and secretary Sara Howard to investigate several murders of male prostitutes.

The trials and triumphs of one of the wealthiest and unhappiest families of the United States, the Gettys. Originally planned to be told over multiple seasons and spanning the twentieth century, the series begins in 1973 with the kidnapping of John Paul Getty III, an heir to the Getty oil fortune, by the Italian mafia in Rome.

Milan, Italy, 1967. Santo Russo, a boy of Calabrian origin, arrives north with his parents and younger brother to find better living conditions. Due to an absurd misunderstanding and his father's contempt, Santo ends up in prison, where he gets a “true education.” In 1978, he and his friends Slim and Mario embark on a 15-year criminal career, a successful and ruthless spiral of robberies, kidnappings, murders and heroin smuggling.

The story about Mirella Antonione Casale who got inspired by her handicapped daughter to lead the fight for including all pupils in public schools in Italy.

Judges Giovanni Falcone and Paolo Borsellino would eventually fall at the hands of Italy’s Cosa Nostra in 1992. However, before that, in 1985, they were preparing for the ‘Mafia Maxi Trial’ when a tip-off of a planned attack against their families sees them taken to an island in Sardinia to wait out the threat. This situation, somewhere between a forced vacation and witness protection, sees the men delve further into their work, the retreat allowing them to hone their case. Fate, however, is not to be escaped, and all too soon danger returns.

With the continuous arrival of migrants to Palermo, a councilor becomes the legal guardian of hundreds of children while also dealing with her own family problems.