Donnie exists as the archetypal weirdo of his hometown, persecuted by bullies, and friend to none his age. He meets a girl named Jenny, who seems just as much an outcast. This new kinship reinvigorates him, and he hopes to start a new life of being accepted. Unfortunately, life just isn't that kind.

At Goode Community Hospital, Dr. Grace Goode tries to keep her bumbling and incompetent staff at the low-income establishment in line during a hectic day of typical rounds and influx of patients arriving for treatment. Things get more complicated when a killer, disguised as a doctor with a mask and scrubs, begins killing staff and patients in a series of horrific and hilarious ways. It's up to Dr. Goode to learn the killer's identity while trying to keep her hospital from being shut down for good.

An insurance investigator examining several recent cases of suicide discovers a demon influencing the deaths, but only he can see it.