New York, 1896. Police commissioner Theodore Roosevelt brings together criminal psychologist Dr. Laszlo Kreizler, newspaper illustrator John Moore and secretary Sara Howard to investigate several murders of male prostitutes.

12-year-old Conor encounters an ancient tree monster who proceeds to help him cope with his mother's terminal illness and being bullied in school.

After getting dumped for the 11th time in a row, Frankie discovers that she has a "loser in love" gene, which predisposes her to chronic failure and rejection for the rest of her life. She decides to embark on a quest to change her romantic future.