Fun-loving San Francisco Police Department investigator Nash Bridges is part of the elite Special Investigations Unit. He tackles crime using his keen sense of humor and charm. Joe Dominguez comes out of retirement to become Bridges' wisecracking yet more rule-abiding partner.

Stefan, a young gay East German medical student, arrives in San Francisco for a medical congress and is following the trail of his dead father, a once high ranking AIDS researcher in the East. Stefan is investigating whether the HIV virus was an incremental result of secret human experiments that were conducted in US prisons in the seventies - a thesis of the Berlin professor, Jakob Segal, which was spread by state agents of former East Germany. At the same time, a serial killer is haunting the gay bars of the city and is killing HIV positive long-term survivors.

A mockumentary examination of Shakespeare's greatest tragedy using "breaking news" style interviews and commentary.