The exploits of a group of men and women who serve the City of New York as police officers, firemen, and paramedics, all working the same fictional 55th precinct during the 3pm to 11pm shift - the 'Third Watch'.

A disease carried by common cockroaches is killing Manhattan children. In an effort to stop the epidemic an entomologist, Susan Tyler, creates a mutant breed of insect that secretes a fluid to kill the roaches. This mutant breed was engineered to die after one generation, but three years later Susan finds out that the species has survived and evolved into a large, gruesome monster that can mimic human form.

After growing up poor in Salmonella, Vincenzo Cortino installs himself as the preeminent, if bumbling, Mafia don of the New World. But now he must pass on power to one of his two sons: either level-headed veteran Anthony or vituperative loose cannon Joey.

A destitute 14-year-old struggles to keep his life together despite harsh abuse at his mother's hands, harsher abuse at his father's, and a growing separation from his slightly older brother.

With his mother dead and his father busy at work, Howie feels adrift in his New York suburb. He and his friend Gary spend their time burglarizing their neighbors' homes — until they make the mistake of robbing the house of Big John, a macho former Marine who is also an unrepentant pedophile. He propositions Howie, who declines, but the two eventually develop an unlikely and dangerous friendship.