A forensic pathologist is about to retire in order to spend some time with his daughter. However, he is forced to continue working when his daughter is kidnapped.

Seon-hwa is a new student at an elite medical school, and she is initiated into a dissection class headed by Dr. Han along with five other students, including her boyfriend Ki-beom. After the first class the students all start to share the same nightmare involving a one-eyed surgeon, and one by one they start to be murdered, the victims being discovered with their hearts removed. Seon-hwa and Ki-beom are convinced that these events are related to a beautiful cadaver with a rose tattoo on her breast, and they begin an investigation to uncover her identity.

On the day of the hundreds billion dollar contract deal just ahead, Jung suddenly disappears after he leaves for a convenient store. Inspector Kim who is desperate to get an exclusive crime case in the hope of drawing media attention finds out that Jung had many jealous colleagues and starts to investigate the case focusing on embezzlement and kidnapping. On the other hand, inspector Park finds out that Jung’s fiancee Mi-sun, a sales manager at the insurance company, has recently took out a life insurance policy on Jung’s life and points her as a suspect. The more investigation goes further the more case gets mysterious and things start to get out of control as a missing case develops to an assault, a kidnapping and finally to a murder.