Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.

When he finds out his longtime girlfriend is pregnant, a commitment-phobe realizes he might have to change his lifestyle for better or much, much worse.

Dr Sloan suspects that his flame of long ago, famous heart surgeon Dr Rachel Walters, has murdered US Senator Cabot on the occasion of a guest operation at the community hospital. After a long investigation, Sloan and fellow detectives Dr Bentley and Dr Parker discover her motive: Years ago, Cabot had caused a hit-and-run accident that put her daughter into coma. But how did Dr Walters manage to pass the deadly bacteria on to the senator in front of TV cameras?

Martin is a total loser, who nobody cares for. When he fails to get a position as guitar player in Lindsay's band and loses his job on the way, he makes a deal with a Voodoo priestess. She promises him the fulfillment of all his dreams if he swears obedience to her. He becomes a rock star and has many women - but to stay alive, he has to kill other people.