Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Dr. Megan Hunt was in a class of her own, a brilliant neurosurgeon at the top of her game. But her world is turned upside down when a devastating car accident puts an end to her time in the operating room. Megan resumes her career as a medical examiner, determined to solve the puzzle of who or what killed the victims.

Jonathan Wright has it all, a prestigious job, incredibly beautiful wife Amy, gorgeous 7-year-old daughter Megan and countless friends. In the prime of his life, Jonathan suffers a life threatening brain aneurysm that leaves him comatose. After regaining consciousness, he begins the grueling task of rebuilding his life.

When Kevin discovers his boyfriend is cheating on their anniversary, his friends come to the rescue to find him a quality person. Of course, the best intentions don't always have the best consequences and he swings from bad date to bad date only to discover what he's been looking for is right next door.

Marissa, an excited bride-to-be, turns into a raging "bridezilla", when she learns her maid of honor has lost her bouquet. Furious about her missing flowers, she throws a hysterical fit, until a tragic accident unravels her momentous day.