After discovering that his late father has gone through most of the family fortune, Tod Stiles hits the title trans-America highway in his Corvette in search of adventure with friend Buz Murdock, a survivor of New York's mean streets. The two work odd jobs as they meet and interact with colorful characters and find themselves plunged into one situation after another, some of them romantic, some of them very dangerous. Later, Linc Case, a Vietnam war hero trying to find himself, takes over as Tod's travel companion.

An axe murderer is loose in a small New England town.

A young woman enters the life of a New York playgirl, after being brutally raped by her stepfather. She soon moves in with a young male doctor, who makes special intimate sessions between government officials and young women.