In the early 21st century, mankind has colonized the oceans. The United Earth Oceans Organization enlists Captain Nathan Bridger and the submarine seaQuest DSV to keep the peace and explore the last frontier on Earth.

Airline security specialist John Cutter, finally returning to the job after his wife's death, finds himself stuck on a flight being hijacked by notorious terrorist Charles Rane. Unfortunately for the terrorists, they're also stuck with him.

Jack Costello is a retired cop and now private detective who lives in Miami, who handles a myriad of cases for unusual clients. At his side are old police buddy Sam Bosley and cartoonist-turned-amateur sleuth Jean Philippe Dumas, who is using Costello as an influence and has nicknamed the burly detective "Extralarge." In the second series, Costello faces other dangerous cases, again with Bosley and Archibald, the son of an old friend, who Costello amusingly nicknames "Dumas."

Two uneasy friends, a police officer and a TV talk show host, each pursue the mysterious "handcuff killer" with the aid of an artist who sees - and draws - the killer's crimes before they're committed.

Fearful that their star witness might be murdered, two attorneys hire a protector to bring him from Los Angeles to New York. Jesse Crowder (Fred Williamson) is a no-nonsense tough guy. He buddies up with the witness, an accountant, and they hit the road. Outwitting their foes means taking all manner of conveyance, including automobile, train, and airplane.