In cases ripped from the headlines, police investigate serious and often deadly crimes, weighing the evidence and questioning the suspects until someone is taken into custody. The district attorney's office then builds a case to convict the perpetrator by proving the person guilty beyond a reasonable doubt. Working together, these expert teams navigate all sides of the complex criminal justice system to make New York a safer place.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

The Fugitive Task Force relentlessly tracks and captures the notorious criminals on the Bureau's Most Wanted list. Seasoned agents oversee the highly skilled team that functions as a mobile undercover unit that is always out in the field, pursuing those who are most desperate to elude justice.

The story of the legalization and subsequent rise of the porn industry in New York’s Times Square from the early ’70s through the mid ’80s, exploring the rough-and-tumble world that existed there until the rise of HIV, the violence of the cocaine epidemic and the renewed real estate market ended the bawdy turbulence of the area.

Tragedy strikes when Chelsea's flight back home crashes in the wilderness. The only other urvivor of the crash, Evelyn King, who just so happens to be a huge fan of Chelsea, pulls her to safety. As Evelyn cares for Chelsea's wounds, she becomes increasingly obsessive. Chelsea begins to realize that her caretaker may have more sinister plans in store and she must find a way to overcome her injuries in order to escape from Evelyn, whose insane adoration may ultimately be Chelsea's demise.