Driven by the desire for the huge reward, Tang Ren tricked Qin Feng to New York, to attend the World Detective Contest. Later on, behind the crazy competition, Qin and Tang discovered the real hidden facts of this contest.

In the Haibei People's Hospital, Qinghai province, China, the present-day on the night of a full moon, a patient is murdered by a syringe through her chest. This adds stress to the hospital's heart surgeon Gu Zhen Sheng who had recently lost his wife Xia Xue to an illness. Since his wife's death, Gu has been suffering from nightmares that have affected his work, and Xia Xue's younger sister, Nurse Xia Xiao Yu also is emotionally disturbed.