Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

In exchange for his freedom, charming con artist Neal Caffrey provides his expertise to help straight-man FBI agent Peter Burke catch elusive white-collar criminals.

Thanks to a Japanese scientist's invention of synthetic blood, vampires have progressed overnight from legendary monsters to fellow citizens. And while humans have been safely removed from the menu, many remain apprehensive about these creatures "coming out of the coffin." Religious leaders, government officials, and vampire fundamentalists around the world have chosen their sides. But in the small Louisiana town of Bon Temps, the jury is still out.

When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.

The lives of staff in the womens' health clinic of a fictitious hospital in Philadelphia.

Every day is a matter of life and death in a hectic New York City hospital, but for Nurse Jackie that's the easiest part. Between chronic back pain that won't quit, and a personal life on the constant edge of collapse, it's going to take a white lie here, a bent rule there, and a handful of secret strategies to relieve the pain, and stay one step ahead of total disaster.

What happens when the biggest stars in the world get too high on the Hollywood hog? When their bank accounts start swelling bigger than their heads? Master prankster Ashton Kutcher is there to punk 'em down to earth.

Broad City follows two women throughout their daily lives in New York City, making the smallest and mundane events hysterical and disturbing to watch all at the same time.

Harriet, Matthew and Malcolm couldn't be any more different, but when they cross paths, they realize they're all looking for a fresh start. The most unlikely of people are starting a law practice in the most unlikely of places -- a rundown shoe store.

On the brink of a midlife crisis, 30-something Mike O'Donnell wishes he could have a "do-over." And that's exactly what he gets when he wakes up one morning to find he's 17 years old again. With his adult mind stuck inside the body of a teenager, Mike actually has the chance to reverse some decisions he wishes he'd never made. But maybe they weren't so bad after all.

It's a brand new life for Cory Baxter when his dad, Victor, becomes the personal chef to the President of the United States. Cory's entrepreneurial scheming reaches new heights as he mingles amongst high-powered Washington D.C. elite.

The lives and internal power struggles of a powerful and wealthy Cuban-American family running an immensely successful rum and sugar cane business in South Florida.

It's the last day of Camp Firewood's season, but there's still time for the big talent show, a little romance… and for everyone to be wiped out by the piece of NASA's Skylab that's hurtling toward Earth.

Matt Burns is many things — loser, dork, pizza delivery boy — but a hero isn't one of them. That is, until he is forced to eat a genetically-engineered tomato that was designed to create super soldiers. A routine pizza delivery turns into a fight for his life, when he accidentally stumbles into the middle of a heated corporate takeover that plans on using this science for world domination. Now, equipped with an indestructible body, advanced strength and a pizza parlor mascot costume, Matt must use his new power to fight evil, rescue the girl and save the day as the unlikeliest of super-heroes: Pizza Man!

Manhattan fireman Mark Decker visits, for the first time, his Steven in his ex Emma's new apartment in one of her dad Donald Richardson's development estates, at the foot of Diamand-back Mountain. But Don's ambitious executive Stewart Hancock, who dreams of his own firm, has been cutting too many corners, at the expense of safety, causing a landslide. Mark gets trapped with Steven and the new concierge Harold, who knows everything about an additional danger: rattlesnakes awoken early from hibernation. Now Mark discovers artistic, nerdy Steven only did 'manly' stuff in the city because dad-son time is so rare. While they soldier on, landscape architect Emma discovers the truth and counters Stewart's plan B to literally cover it up.