The SOKO Stuttgart team investigates analytically and with sensitivity in the likeable state capital. The exciting cases of the series lead them to bizarre crime scenes and to different milieus.

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The sympathetic music teacher Clarissa Springer leads a thoroughly average, but contented life in Freiburg. She lives with her father Walter, whom she has cared for since her mother's death. Although her boyfriend Marco urges her to finally move in with him, Clarissa does not have the heart to let her father "down", at least not so shortly before his 70th birthday. A special, rare guest arrives on Walter's day of honor: Ina, Clarissa's younger sister. Ina, beautiful and internationally successful as a model, turned her back on her homeland years ago and lives in Paris.

After the end of his soccer career, Heimo Körner loses touch with normal life. Only when his stepdaughter Daniela slips into the drug scene he finds a new task: he wants to keep his neighborhood clean with a vigilante group.

Copywriter Lorenz is gay and has a relationship with his boss Adrian. The two are happy together until Lorenz meets secretary Nina one day. Nina has just been abandoned by her husband Kai, who is now with a man. Lorenz also suddenly develops new, unknown feelings. He falls in love with Nina, a woman. Of course, he does everything he can to keep that from Adrian. But that does not hide Lorenz's emotional chaos.