Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Young Cole Carter dreams of hitting the big time as a Hollywood disc jockey, spending his days and nights hanging with buddies and working on the one track that will set the world on fire. Opportunity comes knocking when he meets James Reed, a charismatic DJ who takes the 23-year-old under his wing. Soon, his seemingly clear path to success gets complicated when he starts falling for his mentor's girlfriend, jeopardizing his new friendship and the future he seems destined to fulfill.

Charlie, a down-on-his-luck loner, crosses paths with a blind homeless man who is his exact double. Perplexed and intrigued by the discovery, Charlie invites the man into his life.

College freshman Joe is new to school when he mistakes a rush invitation for a come-on from a cute fraternity brother. He's no less confused after a hazing ritual between him and Christian, his "big brother" in the Greek system, takes and intense and intimate turn. After Joe sets Christian "straight" about his sexual interests, Christian confesses that he himself is straight-but with "issues".